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Efficacy
When cravings arise…
NICORETTE® QuickMist mouthspray is a new and unique format for fast craving relief. Acts fast to help smokers quit.1,2
- Clinically proven to relieve cravings in just 60 seconds (p<0.001)1
- 46% more effective at helping smokers quit compared with placebo at 4 weeks (p<0.05)2
- 2.5 times more effective at helping smokers quit compared with placebo at 52 weeks (p<0.01)2
Why smokers find cigarettes such a difficult relationship to break
Cigarettes are so addictive because of the rapid delivery of a high dose of nicotine to the brain. Due to the short half life of nicotine, smokers require to smoke regularly to maintain a certain level. When nicotine levels drop the cravings for the next cigarette begin.3
Plasma (venous) nicotine profile during 7 hours of cigarette smoking (1 cigarette per hour)
Reinforcing this desired effect of nicotine with each cigarette soon becomes addictive.3
NICORETTE® QuickMist provides rapid absorption of nicotine
Due to its rapid absorption through the oral mucosa, the time to reach maximum plasma nicotine concentration following a single dose is significantly shorter for NICORETTE® QuickMist than with NiQuitin 4 mg lozenge.
Single dose nicotine pharmacokinetics
NICORETTE® QuickMist demonstrated an increase in nicotine level with peak plasma levels reached in less than 10 minutes. In total 58% more nicotine was absorbed with NICORETTE® QuickMist than with NiQuitin 4mg lozenge during the first 10 minutes.5
Smokers can find cravings for nicotine overwhelming
Cravings can strike especially at so called “trigger moments”, making smoking cessation an even bigger challenge. Situations linked to smoking such as at home watching TV, driving the car and socialising may make it difficult to quit.6 Other factors that may influence the smokers’ willpower are
- when under the influence of alcohol7
- where people are smoking and cigarettes are available7
- when particularly stressed7
- in the afternoons and evenings, when withdrawal symptoms may be more frequent and more severe8,9
NICORETTE® QuickMist acts fast on cravings
With NICORETTE® QuickMist you can help your customer in those critical first minutes of a craving when they could cause lapse: NICORETTE® QuickMist is clinically proven to relieve cravings in just 60 seconds with 2x1mg/sprays (p<0.001). It targets craving by providing relief up to 3 times faster than NiQuitin 4mg lozenge (p<0.001).1
Cravings relief in an open label study: NICORETTE® QuickMist 2x1 mg vs. NiQuitin lozenge 4mg
NICORETTE® QuickMist for short and long term efficacy
NICORETTE® QuickMist provides efficacy to help your customer remain abstinent in the long term. As shown in the phase III study NICORETTE® QuickMist proved to be 46% more effective at helping smokers quit vs. placebo at 4 weeks (p<0.05). With NICORETTE® QuickMist your customers are 2.5 times more likely to quit smoking compared to placebo at 52 weeks (p<0.01).5
Sustained abstinence in all smokers
How your customers can use NICORETTE® QuickMist effectively
How to Open:12
- Use your thumb to slide down the button until it can be pushed lightly inwards. Do not push too hard
- While pushing in, slide upwards to unlock the top of the dispenser. Then release the button
How to prime:
- If you are using NICORETTE® QuickMist for the first time or if you have not used the spray for 2 days, you must first prime the spray pump
- Point the spray safely away from you and press the top of the QuickMist firmly with your index finger several times until a fine spray appears
How to use:
- Point the spray nozzle towards the open mouth, holding it as close as possible
- Press the top of the dispenser firmly to release one spray into the mouth, avoiding the lips
- To avoid getting spray down the throat, don't swallow or inhale while spraying
- For best results, don't swallow for a few seconds after spraying
- Use 1 or 2 sprays when cigarettes normally would have been smoked or if cravings emerge button spray nozzle button spray nozzle button spray nozzle button spray nozzle
What you can expect:
- When the spray is released into the mouth, you may initially experience a fresh mint sensation
- One of the most commonly reported side effects is hiccups, the majority of which are mild
- 1.
- Hansson A, et al. Craving Relief With A Novel Nicotine Mouth Spray Form Of Nicotine Replacement Therapy. Poster Presented at SRNT, Feb 16-19th, 2011, Toronto, Canada.
- 2.
- Tonnesen P, et al. Efficacy and safety of a novel nicotine mouth spray in smoking cessation. A randomized, placebo-controlled, double-blind, multi-center study with a 52-week follow-up. Poster Presented at SRNT, Feb 16-19th, 2011, Toronto, Canada.
- 3.
- Nicotine addiction in Britain: a report of the Tobacco Advisory Group of the Royal College of Physicians. London Royal College of Physicians 2000.
- 4.
- Russell MAH, et al. BMJ 1976; 1:1043-1046.
- 5.
- Kraiczi H, et al. Single-Dose Pharmacokinetics Of Nicotine With A Novel Mouth Spray For Nicotine Replacement Therapy. Poster Presented at SRNT, Feb 16-19th, 2011, Toronto, Canada.
- 6.
- Van Gucht D, et al. J Behav Ther & Exp Psychiat 2010; 41: 172-177.
- 7.
- McRobbie H, McEwan A, NICE. Royal Pharmaceutical Society of Great Britain and Pharmacy/HealthLink. 2005.
- 8.
- Fagerstrom KO et al. Psychopharmacology, 1993; 111: 271-277.
- 9.
- Shiffman S, et al. J Consult Clin Pyschol 1996; 64: 366 379.
- 10.
- Ferguson SG, Shiffman S. J Substance Abuse Treatment 2009; 36: 235-243.
- 11.
- Data on File
- 12.
- NICORETTE® QuickMist Patient Information Leaflet.